A Brief Talk About Radiation Wounds

In recent years, the incidence of tumor has been increasing year by year, and it has become an important disease that affects human health and threatens human life. At present, radiation therapy is one of the important methods of tumor treatment, but radiation has certain effects on the human body, such as damage to the tissue cells of the human body, among which radiation skin damage is more common.

Unlike general burns and wounds, rays act on the skin, subcutaneous tissue, muscles, bones and organs. Radiation skin lesions of grade III or above often develop infection and ulcers, which are difficult to heal over time, eventually local tissue fibrosis and progressive necrosis, and even cause body dysfunction and may become cancerous. Therefore, radiation skin damage often seriously affects the quality of life of patients.

Radiation skin injury is divided into acute radiation skin injury and chronic radiation skin injury according to the manifestations of its clinical process. Acute radiation skin injury refers to acute radiation dermatitis and radiation skin ulcers caused by local exposure to large doses of external radiation in one or a short period of time; Chronic radiation dermatitis and chronic radiation skin ulcers caused by long-term radiation exposure.

Pathogenic mechanism:

①The damage of DNA caused by radiation leads to the imbalance of reversible or irreversible DNA synthesis and differentiation, so that skin basal cells cannot generate new cells, and mature epithelial cells continue to be lost.

②Stenosis or thrombosis of small blood vessels caused by radiation, leading to ischemia and hypoxia, thus aggravating the degree of skin damage; in addition, radiation skin damage and ribonucleic acid, deoxyribonucleic acid, protein and other molecules are affected by ionizing radiation, which can cause damage to the body. Molecular excitation and ionization, generation of free radicals, and the presence of oxygen effects lead to macromolecular breakage and intracellular DNA damage, causing replication disorders and errors in the double helix structure.