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Treatment of wound sinus tract
After surgery, once the sutures have been removed and the wound has healed, a small lump may appear a few days later at the puncture site. Pressing on it will cause fluid to ooze o...
Globally, colorectal cancer (CRC) is one of the most common cancers and a leading cause of cancer-related death. A groundbreaking study published in Gut recently revealed the role of lipid metabolism disorders in colorectal cancer and pointed to a possible therapeutic avenue that converts chronic inflammation into an opportunity to treat cancer. The study, led by researchers from the University of South Florida, USA, explored the mechanisms of persistent inflammation in colorectal cancer by integrating lipidomics, targeted molecules, and spatial transcriptomics, and proposed new therapeutic strategies to address these disorders. The study showed that arachidonic acid (AA)-derived lipid mediators (such as leukotrienes) associated with chronic inflammation were significantly upregulated in colorectal cancer tissues, while pro-resolution mediators (such as lipoxins) were almost absent. Background: The role of chronic inflammation in the progression of colorectal cancer has been highlighted, often attributed to an imbalance between pro-inflammatory and inflammatory resolution or pro-resolving processes. During normal wound healing, a process called lipid mediator class switching leads to a transition from inflammation to resolution, which also involves molecules such as lipoxins and resolvins. However, colorectal cancer appears to exhibit impaired class switching, resulting in persistent inflammation. The research team used a multimodal approach to examine lipid metabolism in colorectal cancer using 81 paired tumor and normal tissue samples. Untargeted lipidomics analysis focused on 40 paired samples, while targeted lipidomics assessed AA pathway-related mediators. Liquid chromatography tandem mass spectrometry (LC-MS/MS) was used for both untargeted and targeted lipidomics analysis. Results: Colorectal cancer tissues exhibited a distinct pro-inflammatory lipid profile compared with normal tissues. Quantitative lipidomic analysis revealed elevated levels of AA-derived mediators associated with the enzyme ALOX5, including leukotrienes and 5-hydroxyeicosatetraenoic acid (5-HETE). In contrast, pro-resolving mediators, such as lipoxins, were significantly deficient, suggesting a defect in lipid mediator class switching. In terms of therapeutic significance, the researchers proposed "dissipative medicine", emphasizing the therapeutic potential of specialized pro-dissipative mediators (SPMs) such as dissipatives and protectins in restoring lipid metabolic balance. Gene expression analysis also revealed overexpression of pro-inflammatory genes in colorectal cancer tissues, such as ALOX5, ALOX5 activation protein (ALOX5AP), and leukotriene-A4 hydrolase (LTA4H). These genes are closely associated with inflammatory biomarkers and macrophage markers, emphasizing the role of tumor-associated macrophages (TAMs) in maintaining inflammation. Lipidomic analysis revealed specific structural lipid changes, including enrichment of phospholipids containing linoleic acid and AA. These changes were also associated with chronic inflammation and tumor progression, suggesting metabolic disturbances in the tumor microenvironment. The researchers concluded that a distinct imbalance between pro-inflammatory and resolving mediators underlies the persistent inflammatory state in colorectal cancer. By identifying these key molecular and cellular mechanisms, the study provides insights into potential therapeutic strategies that could focus on restoring lipid class switching through endogenous or exogenous pro-resolving mediators. Journal reference: Soundararajan, R., Maurin, MM, Rodriguez-Silva, J., Upadhyay, G., Alden, AJ, Gowda, SB, Schell, MJ, Yang, M., Levine, NJ, Gowda, D., Sundaraswamy, PM, Hui, S., Pflieger, L., Wang, H., Marcet, J., Martinez, C., Bennett, RD, Chudzinski, A., Karachristos, A., & Nywening, TM (2024). Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer.
Our solutions start with a need. Patients and healthcare professionals inspire us to design medical solutions for wound management, surgery and pressure ulcer prevention. We want to enhance performance at every point of care – from the operating room to the home.
After surgery, once the sutures have been removed and the wound has healed, a small lump may appear a few days later at the puncture site. Pressing on it will cause fluid to ooze o...
When you have a wound, most people first think of disinfection and dressing changes, rarely connecting the pills they take daily to the wound. In fact, many commonly used medicatio...
Regarding scarring, you need to understand that many people focus all their energy on making wounds heal as quickly as possible. Only after the wound has completely healed do they ...
For those caring for wounds at home, the most pressing and anxiety-inducing question is whether the wound is healing. Looking at the wound under the dressing, the daily changes may...
Hand-foot syndrome, also known as palmoplantar erythema with loss of sensation, is a skin toxicity reaction caused by certain chemotherapy drugs or targeted therapies. Its patholog...
Facial abrasions in children are common in pediatric emergency rooms and primary care clinics. Children are highly active, and their self-protection awareness and motor coordinatio...
Skin abrasions, cuts, or lacerations during sports are the most common types of injuries seen in primary care clinics and sports medicine facilities. While sports like soccer, bask...
The granulation phase of wound healing signifies the near end of the inflammatory stage, with bright red or pink granular new tissue appearing on the wound surface. Granulation tis...
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